AML with inv(16)(p13q22) or t(16;16)(p13;q22), (CBFB/MYH11)

Definition

Acute myeloid leukemia with inv(16)(p13q22) or t(16;16)(p13;q22), (CBFB/MYH11) is an acute myeloid leukemia with monocytic and granulocytic differentiation. They are also characterized  by a characteristically abnormal eosinophilia in the bone marrow. This combination is commonly referred to as AMML Eo. (FAB M4)

Sample Cases

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Epidemiology

The inv(16)(p13;q22) is found in approximatley10-12% of cases of AML. It can occur in all age groups but is predomantly seen in younger patients.

Possible causes

Morphology

Immunophenotyping

Other relevant tests

Sub-classification

Flow Diagnosis

References

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